Haloacetylated enol ethers. 8 [12]. Reaction of β-alkoxyvinyl trihalomethyl ketones with guanidine hydrochloride. Synthesis of 4-trihalomethyl-2-aminopyrimidines

✍ Scribed by Nilo Zanatta; Maria de F. M. Cortelini; Marcos J. S. Carpes; Helio G. Bonacorso; Marcos A. P. Martins

• Publisher: Journal of Heterocyclic Chemistry
• Year: 1997
• Tongue: English
• Weight: 309 KB
• Volume: 34
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570340226

✦ Synopsis

Abstract

In this work the results of the reaction of β‐alkoxyvinyl trihalomethyl ketones 1, 2a‐e, with guanidine hydrochloride are reported. Depending on the ketone 1 or 2 and the conditions under which the reactions were carried out, 4‐trihalomethyl‐2‐amino pyrimidines, β‐alkoxyvinyl carboxylic acids, or β‐acetal carboxylic esters were obtained.