Hair analysis for Δ9-THC, Δ9-THC-COOH, CBN and CBD, by GC/MS-EI: Comparison with GC/MS-NCI for Δ9-THC-COOH

Rapid and robust confirmation and quanti

Rapid and robust confirmation and quantification of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in urine by column switching LC-MS-MS analysis

✍ Gabriele Zanchetti; Ivan Floris; Alberto Piccinotti; Silvia Tameni; Aldo Poletti 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 327 KB

A method for the rapid and robust confirmation of 11‐nor‐∆9‐tetrahydrocannabinol‐9‐carboxylic acid (THCA) in urine involving basic hydrolysis with NaOH and direct injection of the hydrolysate in a column‐switching LC‐MS‐MS system was developed and validated. THCA‐d3 was used as internal standard. De