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Haemophilia A mutations in the UK: results of screening one-third of the population

✍ Scribed by P. M. Green; R. D. Bagnall; N. H. Waseem; F. Giannelli


Book ID
108675921
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
519 KB
Volume
143
Category
Article
ISSN
0007-1048

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A combination of Southern blotting and the analysis of polymerase chain reaction (PCR) amplified DNA fragments was used to screen the factor VIII genes of 527 haemophilia A patients for point mutations within TaqI restriction sites. Since this "directed search" strategy yielded only four gene lesion