Haemodynamic effects of a new beta-adrenergic blocker (Trasicor�) in man when supine and sitting

✍ Scribed by Ulrych, Milo? ;Chrpov�, Vara

• Publisher: Springer-Verlag
• Year: 1968
• Weight: 616 KB
• Volume: 1
• Category: Article
• ISSN: 0369-9498
• DOI: 10.1007/bf00418711

✦ Synopsis

The haemodynamie effects of CIBA 39 089-Ba (Trasicor) were studied in 17 subjects with normal or increased arterial pressure and marked differences in cardiac index. Studies were performed in both the supine and the sitting position. --In the supine position there were no changes in mean arterial pressure, a 3% decrease in cardiac output, 5% decrease in heart rate, a 2~o increase in stroke volume and little change in total peripheral vascular resistance after Trasicor administration (5 mg i.v.). In the sitting position the changes after Trasicor administration were about --2% for mean arterial pressure, --10% for cardiac output, --8% for heart rate, --2% for stroke volume and + 8 ~/o for total peripheral vascular resistance. --The difference between Trasicor effects in supine and sitting positions is most probably due to the different amount of sympathetic nervous activity in these positions. The same may be true for the differences in effects between different subjects. --The haemodynamic effects of Trasicor are different from those of propranolol and resemble those of pronethalol.