Experimental chemotherapy of schistosomi
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J. Pellegrino; Fernanda F. Lima-Costa; Miriam A. Carlos; Rômulo T. Mello
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Article
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1977
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Springer-Verlag
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English
⚖ 852 KB
In mice experimentally infected with Sehistosoma mansoni, praziquantel (2-cyclohexylcarbonyl-1,3,4,6,7,11 b-hexahydro-2H-pyrazino[2,1a]isoquinoline-4-one), administered orally at the levels of 100 and 50 mg/kg, for 5 consecutive days, produced oogram changes in all animals and a pronounced hepatic s