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HA14-1 sensitizes TNF-α-induced apoptosis via inhibition of the NF-κB signaling pathway: Involvement of reactive oxygen species and JNK

✍ Scribed by Dong-Oh Moon; Mun-Ock Kim; Sang-Hyuck Kang; Yung Hyun Choi; Sung Yong Park; Gi-Young Kim


Book ID
116335392
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
855 KB
Volume
292
Category
Article
ISSN
0304-3835

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl