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Ha-rasVal12Oncogene Increases Susceptibility of NIH/3T3 Cells to Lovastatin

✍ Scribed by Meng-Yao Chang; Ming-Shiou Jan; Shen-Jeu Won; Hsiao-Sheng Liu

Book ID
115582337
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
165 KB
Volume
248
Category
Article
ISSN
0006-291X

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The ornithine decarboxylase (odc) gene is an early response gene, whose increased expression and relaxed chromatin structure is closely coupled to neoplastic growth. In various turnour cells, the odc gene displays hypomethylation at the sequences CCGG. Hypomethylation of genes is believed to correla