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Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis

✍ Scribed by Juan F. Santibañez; Claudia Hurtado


Book ID
116466121
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
313 KB
Volume
579
Category
Article
ISSN
0014-5793

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In this study, we examined the susceptibility of various oncogene-transformed NIH/3T3 cells to apoptosis induced by alkylating agents. Only v-Ha-ras-transformed cells showed marked resistance to apoptotic death induced by these drugs. Upon treatment with methylmethane sulfonate (MMS), NIH/3T3 cells