H2O2-induced cross-protection against UV-C killing in Escherichia coli is blocked in a lexA (Def) background
✍ Scribed by Lı́dia M.B.O Asad; Aline A de Carvalho; Israel Felzenszwalb; Alvaro C Leitão; Nasser R Asad
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 130 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1011-1344
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✦ Synopsis
Pretreatment with 2.5 mM H 2 O 2 protects E. coli cells against UV-C killing, a phenomenon independent of LexA cleavage. In this paper, we observe that this cross-protection response is neither dependent on the dinY gene product nor on the system that controls dinY, since H 2 O 2 is able to induce cross-protection but not to induce the dinY gene in a lexA-noninducible strain [lexA (Ind y )]. Moreover, this response is not induced in a lexA (Def) background, suggesting that the expression of the SOS regulon may inhibit this cross-protection response.