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H2A and H2B tails are essential to properly reconstitute nucleosome core particles

✍ Scribed by Aurélie Bertin; Dominique Durand; Madalena Renouard; Françoise Livolant; Stéphanie Mangenot

Book ID
105946364
Publisher
Springer
Year
2007
Tongue
English
Weight
579 KB
Volume
36
Category
Article
ISSN
1432-1017

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✍ Rufus W. Burlingame; Robert L. Rubin 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 650 KB

Chromatin, a huge polymer of nucleosomes, has been implicated as an important target of autoantibodies in idiopathic and drug-induced lupus for decades, but the antigenicity of chromatin has only recently been dissected. IgG reactivity with the (H2A-H2B)-DNA complex, a subunit of the nucleosome, is