H2-Antihistaminika, 11. Mitt.1) Zyklische Guanidine mit H2-antihistaminischer Wirkung

✍ Scribed by Jan-Peter Spengler; Walter Schunack

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 300 KB
• Volume: 316
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19833160116

✦ Synopsis

Reaction of 14a, b with hydrazines

A solution of 0.01 mole of 14a or 14b in 20 ml ethanol was treated with 0.012 mole hydrazine hydrate or phenyl-hydrazine. The reaction mixture was refluxed for 30 min, then evaporated. The remaining product was triturated with water and acidified with concentrated hydrochloric acid. The solid product was crystallised. Compounds 15 and 16 are listed in table 1. The IR spectral data are listed in table 2.