H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

✍ Scribed by Nurmatov, Ulugbek B.; Rhatigan, Edmund; Simons, F. Estelle R.; Sheikh, Aziz

• Book ID: 122326768
• Publisher: Elsevier Science
• Year: 2014
• Tongue: English
• Weight: 368 KB
• Volume: 112
• Category: Article
• ISSN: 1081-1206
• DOI: 10.1016/j.anai.2013.11.010

✦ Synopsis

Background:

Anaphylaxis is a serious allergic or hypersensitivity reaction, which is rapid in onset and sometimes can prove fatal. although h2-antihistamines are often administered for emergency treatment in anaphylaxis, there is uncertainty about their effectiveness in this disease.

Objective:

To assess the benefits and harms of h2-antihistamines in the treatment of anaphylaxis.

Methods:

A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing h2-antihistamines with placebo or no intervention in patients with anaphylaxis.

Results:

The authors failed to identify any eligible studies for inclusion in this systematic review.

Conclusion:

When h2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. well-designed randomized controlled trials investigating the role of h2-antihistamines in anaphylaxis treatment are urgently needed.