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H-, K- and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanism

✍ Scribed by Delgado, M Dolores; Vaqué, J Pedro; Arozarena, Imanol; López-Ilasaca, Marco A; Martínez, Carlos; Crespo, Piero; León, Javier


Book ID
110062730
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
415 KB
Volume
19
Category
Article
ISSN
0950-9232

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We investigated the possible involvement of HTLV-1 Tax in the transcriptional activation of p21/Waf1/Cip1 (hereafter p21), a potent inhibitor of cyclin-dependent kinases and cell growth. Tax transfection resulted in enhanced expression of p21 protein in T and fibroblastoid cells. Similarly, Tax-expr