H-2-linked murine cytotoxic T cell responses specific for sendai virus-infected cells

✍ Scribed by R. Kurrle; M. Röllinghoff; H. Wagner

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 288 KB
• Volume: 8
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830081216

✦ Synopsis

Abstract

CBA (H‐2^k^) mouse‐derived lymphochoriomeningitis virus and herpes simplex virus‐specific cytotoxic T lymphocytes lyse virus‐infected target cells compatible on either the H‐2K or H‐2D region. In contrast, CBA, C3H and AKR (H‐2^k^) mouse‐derived sendai virus‐specific cytotoxic T lymphocytes (CTL) fail to lyse H‐2D‐compatible virus‐infected cells. A similar lack of H‐2D region‐associated lytic activity was found with C57BL/6 and C57BL/10 (H‐2^b^) mice as well as with the recombinants B 10.A (2R) [K^k^‐D^b^]and B10.A (4R) [K^k^‐D^b^]. On the other hand, BALB/c (H‐2^d^) mice and A/J (H‐2^a^) mice do generate H‐2D^d^‐associated sendai virus‐specific CTL. These results are in contrast to those obtained with (CBA x BALB/c)F~1~ and B10.HTT [K^s^‐D^d^] mice, which failed to mount D^d^ region‐associated CTL responses. It is concluded that D region‐associated sendai virus‐specific CTL responsiveness varies with the H‐2 genotype of the responder cells.