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Gα13 mediates activation of the cytosolic phospholipase A2α through fine regulation of ERK phosphorylation

✍ Scribed by Stefania Mariggiò; Aljosa Bavec; Elena Natale; Pasquale Zizza; Mario Salmona; Daniela Corda; Maria Di Girolamo


Book ID
113527979
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
824 KB
Volume
18
Category
Article
ISSN
0898-6568

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✍ Robert E. Gundersen 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB 👁 1 views

The Ga2-subunit of Dictyostelium discoideum is essential to the initial stage of the cell's developmental life cycle. In response to the extracellular chemoattractant, cAMP, Ga2 is activated and transiently phosphorylated on serine-113 [Chen et al. (1994): J Biol Chem 269:20925-20930]. The role of G