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Gα12 is critical for TCR-induced IL-2 production and differentiation of T helper 2 and T helper 17 cells

✍ Scribed by Hee Yeon Won; Hyun Jung Min; Woo Hyung Lee; Sang Geon Kim; Eun Sook Hwang

Book ID: 116300062
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 646 KB
Volume: 394
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.03.079

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## Abstract Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice. We investigated how AHR ligands affected human T‐cell polarization. We found that the high affinity and stable AHR‐liga