Sirtuins and the hepatic regulation of e
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Puneet Puri; Arun J. Sanyal
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Article
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2009
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John Wiley and Sons
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English
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The fasting-activated longevity protein sirtuin 1 (SirT1) promotes gluconeogenesis in part, by increasing transcription of the key gluconeogenic genes pepck1 and g6pase, through deacetylating PGC-1โฃ and FOXO1. In contrast, signal transducer and activator of transcription 3 (STAT3) inhibits glucose p