Gut-derived effector T cells circulating in the blood of the rat: preferential re-distribution by TGFβ-1 and IL-4 maintained proliferation

CD4+ effector T cell distribution in viv

CD4+ effector T cell distribution in vivo: TGF-β1/TGF-β receptor II interaction during activation mediates accumulation in the target tissue by preferential proliferation

✍ Ulrike Bode; Kerstin Tiedemann; Jürgen Westermann 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB

## Abstract CD4^+^ effector T cells generated in mesenteric lymph nodes (mLN) leave into the blood. Although they enter many tissues, mLN effector T cells are later found preferentially in the gut,the drainage area of mLN. We show in the rat that this is not an intrinsic property of mLN T cells. In