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Guilty until proven innocent: the case of NPC1 and cholesterol

✍ Scribed by Yiannis A. Ioannou

Book ID: 113931217
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 422 KB
Volume: 30
Category: Article
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2005.07.007

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## Abstract The Niemann‐Pick C1 and C2 (NPC1 and NPC2) proteins have a central role in regulating the transport of lipoprotein‐derived cholesterol from endocytic compartments to the endoplasmic reticulum for esterification by acyl‐CoA:cholesterol acyltransferase (ACAT) and feedback inhibition of th