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Guillain-Barré syndrome in immunocompromised patients: A report of three patients and review of the literature

✍ Scribed by Adnan I. Qureshi; Albert A. Cook; Husham P. Mishu; David A. Krendel

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
172 KB
Volume
20
Category
Article
ISSN
0148-639X

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✦ Synopsis

Both humoral and cell-mediated autoimmune mechanisms have been implicated in the pathogenesis of Guillain-Barre ´syndrome (GBS). Therefore, its occurrence in severely immunocompromised patients is not expected. We identified 3 severely immunocompromised patients who developed GBS. Two of the 3 patients had acquired immunodeficiency syndrome with CD4 counts of 5 and 4 cells/mm 3 , respectively. One post-cardiac transplant patient was taking azathioprine and cyclosporine at the time of onset of GBS. In all 3 patients, immunocompromise was induced by infectious or chemotherapeutic agents which preferentially suppress Tlymphocyte responses. All 3 had severe lymphocytopenia and incomplete recovery. We conclude that GBS can occur in patients with severe t-cell suppression. Although no conclusion regarding prognosis can be drawn from our small group of patients, their incomplete recovery is consistent with the idea that T-cells are important for recovery.

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