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Guided selection of an anti-gamma-seminoprotein human Fab for antibody directed enzyme prodrug therapy of prostate cancer

✍ Scribed by Qing Zhang; Si-He Zhang; Ming-Quan Su; Guo-Qiang Bao; Jia-Yun Liu; Jing Yi; Jian-Jun Shen; Xiao-Ke Hao


Book ID
105967125
Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
720 KB
Volume
56
Category
Article
ISSN
0340-7004

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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar