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Guidance of neurite outgrowth by pathways of substratum-adsorbed laminin

โœ Scribed by J.A. Hammarback; S.L. Palm; L.T. Furcht; P.C. Letourneau

Book ID
102910590
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
892 KB
Volume
13
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

Neurite outgrowth is guided by narrow pathways of bioactive laminin. These pathways are created by ultraviolet light irradiation of laminin-coated coverslips masked with electron microscope grids. Patterned outgrowth of neurites is independent of gross mechanical guidance and guidance caused by substrate limitation. Cells on unirradiated laminin are less readily displaced by shear forces than cells on irradiated laminin. This study suggests that ultraviolet light alters the adhesive properties of laminin and that differential cell-substratum adhesion may guide extending neurites on the purified naturally occurring substance, laminin.

๐Ÿ“œ SIMILAR VOLUMES

Neuronal migration in cerebellar microcu
Neuronal migration in cerebellar microcultures is inhibited by antibodies against a neurite outgrowth domain of laminin
โœ P. Liesi; I. Seppรคlรค; E. Trenkner ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 803 KB

The functional role of laminin in neuronal migration was investigated by using polyclonal antibodies or their divalent (Fab'), fragments to a neurite outgrowth promoting domain of the B2 chain of laminin in a cerebellar microculture system widely recognized as a model for neuronal migration. We show