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GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

✍ Scribed by Xosé R. Bustelo; Vincent Sauzeau; Inmaculada M. Berenjeno

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 510 KB
Volume: 29
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.20558

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✦ Synopsis

Abstract

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley Periodicals, Inc.

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