𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Grubbs′ RCM in the Total Synthesis of the Microtubule Stabilizing Drug Laulimalide.

✍ Scribed by Johann Mulzer; Elisabeth Oehler; Valentin S. Enev; Martin Hanbauer

Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
33
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Grubbs' RCM in the Total Synthesis of th
Grubbs' RCM in the Total Synthesis of the Microtubule Stabilizing Drug Laulimalide
✍ Johann Mulzer; Elisabeth Öhler; Valentin S. Enev; Martin Hanbauer 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB 👁 2 views

Two independent syntheses of the microtubule stabilizing antitumor agent laulimalide are described, which mainly differ with respect to the macrocyclization step. The first synthesis employs a Still±Gennari olefination and the second one an Alexakis-type, allylsilane/acetal addition to close the fin