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GRP94 in ER quality control and stress responses

โœ Scribed by Davide Eletto; Devin Dersh; Yair Argon


Book ID
116881596
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
507 KB
Volume
21
Category
Article
ISSN
1084-9521

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Geldanamycin, a benzoquinone ansamycin, binds specifically to hsp90 and GRP94 in vitro and in vivo. Treatment of cells with geldanamycin alters the molecular chaperone function of hsp90, and as a result, blocks certain cytosolic proteins from reaching their mature form, inhibits their activity, and/