Several angiogenic preparations that have been shown to stimulate plasminogen activator (PA) and collagenase production by cultured bovine capillary endothelial (BCE) cells were tested for their ability to stimulate BCE cell motility in the phagokinetic track assay. Bovine retinal extract, medium co
Growth stimulation of bovine endothelial cells by vitamin A
β Scribed by G. Melnykovych; K. K. Clowes
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 522 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Retinol at concentrations of 10^β6^ and 10^β5^ M stimulated growth of bovine aortic endothelial cells maintained in Eagle's MEM supplemented with delipidized serum. In addition to retinol, retinal, retinoic acid, and retinyl acetate were also growth stimulatory. At very low inoculum densities (4β40 cells/cm^2^) the growth promoting effect could be demonstrated only in the presence of conditioned medium from macrophageβlike culture P388D. When added to media containing whole (nondelipidized) serum, retinol was growth inhibitory at 10^β6^ and 10^β5^ M concentrations.
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