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Growth State-Dependent Binding of USF-1 to a Proximal Promoter E Box Element in the Rat Plasminogen Activator Inhibitor Type 1 Gene

✍ Scribed by Lisa A. White; Carolyn Bruzdzinski; Stacie M. Kutz; Thomas D. Gelehrter; Paul J. Higgins


Book ID
115603797
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
234 KB
Volume
260
Category
Article
ISSN
0014-4827

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The type-1 inhibitor of plasminogen activator (PAI-1) is a major physiologic regulator of pericellular proteolytic activity and, as such, influences matrix integrity, cell-to-substrate adhesion, and cellular proliferation. Excessive accumulation of both PAI-1 mRNA and protein correlates with the pro