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Growth Properties and Growth Factor Responsiveness in Skin Fibroblasts from Centenarians

✍ Scribed by Giuseppina Tesco; Marco Vergelli; Emanuela Grassilli; Paolo Salomoni; Enrica Bellesia; Ewa Sikora; Ewa Radziszewska; Daniela Barbieri; Stefania Latorraca; Umberto Fagiolo; Silvia Santacaterina; Luigi Amaducci; Roberta Tiozzo; Claudio Franceschi; Sandro Sorbi

Book ID
115581805
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
235 KB
Volume
244
Category
Article
ISSN
0006-291X

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Substance P (SP), fibroblast growth factor (FCF), and epidermal growth factor (EGF) are mitogens for fibroblasts. EGF acts as a progression factor, whereas FGF and SP have competence factor activity. The ability of eicosanoids to regulate proliferation of fibroblasts and the increased production of