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Growth preferences of adult rat retinal ganglion cell axons in retinotectal cocultures

✍ Scribed by Wizenmann, Andrea ;B�hr, Mathias

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
139 KB
Volume
35
Category
Article
ISSN
0022-3034

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✦ Synopsis

We examined whether regenerating a choice between superior colliculus and inferior colliaxons from adult rat ganglion cells are able to recognize culus, axons from nasal retina preferentially grew totheir appropriate target region in vitro. Explants from ward the posterior superior colliculus and avoided the adult rat retina were cocultured with embryonic sagitinferior colliculus. In contrast, temporal axons in the tal midbrain slices in Matrigel R . The midbrain sections same assay did not show preference for either of the contained the superior colliculus, the main target for colliculi. These findings suggest that regenerating axons retinal ganglion cell axons in rats, and the inferior collifrom adult rat retina are able to recognize target-speculus. We observed a statistically significant preference cific guidance cues released from embryonic midbrain of both temporal and nasal retinal axons to grow totargets in vitro. ᭧ 1998 John Wiley & Sons, Inc. J Neurobiol 35: ward their appropriate target region (anterior and pos- [379][380][381][382][383][384][385][386][387] 1998 terior superior colliculus, respectively). No preferential

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