## Abstract All‐trans‐retinoic acid (ATRA) has been shown to inhibit the growth of a number of ovarian tumor cell lines while others have been found to be resistant to retinoid suppression of growth. Interestingly, two synthetic retinoids, CD437 and 4‐HPR, inhibit the growth of both ATRA‐sensitive
Growth-inhibitory effects of the synthetic retinoid CD437 against ovarian carcinoma models in vitro and in vivo
✍ Scribed by Simon P. Langdon; Genevieve J. Rabiasz; Alison A. Ritchie; Uwe Reichert; Peter Buchan; William R. Miller; John F. Smyth
- Book ID
- 105994403
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 161 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0344-5704
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## Abstract A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. __In vitro__, this cell line is estrogen receptor (ER)‐positive and its growth is stimulated by 17 β‐estradiol at concentrations between 10^−12^ and 10^−6^ M. When xenografted, PE04 cells r
## Abstract Fenretinide, __N__‐(4‐hydroxyphenyl)retinamide (4‐HPR) is an aminophenol‐containing synthetic retinoid derivative of all‐__trans__‐retinoic acid, which is a potent chemopreventive and antiproliferative agent against various cancers. Clinical studies of 4‐HPR have shown side effects cons