✦ LIBER ✦

Growth inhibitory effects of interferon on normal and malignant human haemopoietic cells

✍ Scribed by Frances R. Balkwill; R. T. D. Oliver

Publisher: John Wiley and Sons
Year: 1977
Tongue: French
Weight: 498 KB
Volume: 20
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910200405

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A study of the effects of human leukocyte and lymphoblastoid interferon preparations on the growth of normal, immune and malignant haemopoietic cells has been carried out. At a standard dose of 10,000 U/ml, incorporation of tritiated thymidine ([^3^H] TdR) was reduced by 7–92% of control values, and cell survival by 35–82% in acute myelogenous leukaemia cell cultures, whereas in normal bone‐marrow cultures interferon showed a 58–62% reduction in [^3^H] TdR uptake but only up to 13% reduction in cell survival. [^3^H] TdR incorporation by MLC‐stimulated lymphocytes was also significantly reduced by interferon but the blastogenic response to PHA was not. These effects of interferon were shown to be dose‐dependent. The problems of using interferon in the treatment of AML in the light of these findings are discussed.

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