Growth inhibition of human gastrointestinal cancer xenograft lines by treatment with CPT-11 and VP-16
✍ Scribed by Dr. Satoshi Nagai; Masaji Yamauchi; Tetsuya Satta; Yasuhiro Kodera; Ken Kondou; Seiji Akiyaya; Katsuki Ito; Hiroshi Takagi
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 316 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
✦ Synopsis
A water-soluble and stable camptothecin derivative, CPT-I 1, was found to possess a strong antitumor activity against various murine tumors. In the present study, CPT-I 1 was tested against ten human gastrointestinal cancer xenograft lines carried by nude mice. CPT-11 was very effective against nine xenograft lines, with the exception of one xenograft. On the other hand, VP-16 was ineffective against all these xenograft lines. Therefore, CPT-11 is expected to be clinically more effective against gastrointestinal cancer than the top0 I1 targeting agent.