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Growth inhibition by protein kinase C late in mitogenesis

✍ Scribed by Huang, Chou-Long; Ives, Harlan E.


Book ID
109751028
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
234 KB
Volume
329
Category
Article
ISSN
0028-0836

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Sphingosine reverses growth inhibition c
✍ Robert H. Weiss; Chou-Long Huang; Harlan E. Ives πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 621 KB

## Abstract In certain cell systems, including neonatal vascular smooth muscle (VSM) cells, phorbol esters are growth inhibitory. Here we show that 1, 2‐dioctanoyl‐snglycerol (DiC8), when added 2 h after α‐thrombin, reverses by 95% the induction of DNA synthesis in VSM cells by α‐thrombin. Sphingos