The 18qΨ syndrome is one of the commonest deletion syndromes. Clinical characteristics are variable but may include: hypotonia, tapered digits, "carp-like" mouth, mental retardation, and hearing impairment. Growth failure (GF; both weight and height <3%) was reported in 80% of affected individuals.
Growth hormone benefits children with 18q deletions
β Scribed by Jannine D. Cody; Margaret Semrud-Clikeman; L. Jean Hardies; Jack Lancaster; Patricia D. Ghidoni; Rebecca L. Schaub; Nora M. Thompson; Lynda Wells; John E. Cornell; Tanzy M. Love; Peter T. Fox; Robin J. Leach; Celia I. Kaye; Daniel E. Hale
- Book ID
- 101450930
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 117 KB
- Volume
- 137A
- Category
- Article
- ISSN
- 1552-4825
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Growth hormone insufficiency is a common cause of growth failure in children with the 18q-syndrome. Individuals with this syndrome have a deletion as large as 36 Mb from the long arm of chromosome 18. We have evaluated 33 children with this syndrome for growth hormone production and have identified
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