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Growth hormone benefits children with 18q deletions

✍ Scribed by Jannine D. Cody; Margaret Semrud-Clikeman; L. Jean Hardies; Jack Lancaster; Patricia D. Ghidoni; Rebecca L. Schaub; Nora M. Thompson; Lynda Wells; John E. Cornell; Tanzy M. Love; Peter T. Fox; Robin J. Leach; Celia I. Kaye; Daniel E. Hale


Book ID
101450930
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
117 KB
Volume
137A
Category
Article
ISSN
1552-4825

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The 18q؊ syndrome is one of the commonest deletion syndromes. Clinical characteristics are variable but may include: hypotonia, tapered digits, "carp-like" mouth, mental retardation, and hearing impairment. Growth failure (GF; both weight and height <3%) was reported in 80% of affected individuals.

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## Abstract The deletion of the long arm of chromosome 18 causes a contiguous gene deletion syndrome with a highly variable phenotype, usually related to the extent of the deleted region. The most commonly reported clinical features include: decreased growth, microcephaly, facial abnormalities, hyp

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Marker chromosomes carried by unrelated 3 cases were identified as a part of No. 9 chromosome through the analysis of the chromatid fine structure after trypsin-giemsa treatment. They showed characteristic features of that 9p trisomic syndrome which were described by RethorΓ© et al. (1973). In additi