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Growth factors VEGF and TGF-β1 in peritoneal dialysis

✍ Scribed by Machteld M Zweers; Dirk R de Waart; Watske Smit; Dirk G Struijk; Raymond T Krediet


Book ID
114054206
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
811 KB
Volume
134
Category
Article
ISSN
1532-6543

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Transforming growth factor-beta 1 (TGF-β
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## Abstract VEGF and TGF‐β1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF‐β1 induces apoptosis. We have previously shown that VEGF/VEGF receptor‐2 (VEGFR2) signaling mediates TGF‐β1 induction of apoptosis. This finding raised