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Growth factors sustain primordial germ cell survival, proliferation and entering into meiosis in the absence of somatic cells

✍ Scribed by Donatella Farini; Maria Lucia Scaldaferri; Saveria Iona; Gina La Sala; Massimo De Felici

Book ID: 116975291
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 329 KB
Volume: 285
Category: Article
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2005.06.036

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## Abstract ## BACKGROUND Germ cell tumors (GCTs) in adolescent and young males are very sensitive to cisplatin‐based chemotherapy. However, 10–20% of the patients cannot be cured by currently available therapeutic options. Once a tumor does not respond to cisplatin, current therapeutic modalities