Platelet-derived growth factor (PDGF) is a 30 kDa protein consisting of disulfide-bonded dimers of Aand B-chains. PDGF receptors are of two types, a-and @-receptors, which are members of the protein-tyrosine kinase family of receptors. The receptors are activated by ligand-induced dimerization, wher
Growth Factors in Gliomas Revisited
β Scribed by W. Hamel; M. Westphal
- Publisher
- Springer Vienna
- Year
- 2000
- Tongue
- English
- Weight
- 274 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0001-6268
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Expression of c-Met, the receptor for hepatocyte growth factor (HGF). and the biological roles of HGF were examined in cultured human glioma cells. All of the 5 glioma cell lines examined expressed c-Met protein as well as the c-met gene. Expression of the c-met gene was also confirmed in a glioblas