## Abstract Growth factors are members of a large functional group of polypeptide regulatory molecules that influence the biological activities of responsive cells. In the last decade, the use of a variety of growth factors as therapeutic agents to improve wound healing and the viability of ischemi
Growth factors as survival factors: Regulation of apoptosis
✍ Scribed by Mary K. L. Collins; Gordon R. Perkins; Gemma Rodriguez-Tarduchy; Maria Angela Nieto; Abelardo López-Rivas
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 785 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The generation of neurons and glia in the developing nervous system is likely to be regulated by extrinsic factors, including growth factors and neurotransmitters. Evidence from in vivo and/or in vitro systems indicates that basic fibroblast growth factor, transforming growth factor (TGF)-alpha, ins
Glial cells recently are being appreciated as supporters of brain neurons. This review addresses their role as growth factor providers. While the function of astrocytes in this capacity is known, new data indicate that oligodendrocytes, the myelinating cells of the brain, exhibit similar abilities.
## Abstract Previous studies showed that nerve growth factor (NGF) decreases the proliferation of neuroectodermal tumor (NET) cells (C‐1300 and Neuro2A murine neuroblastoma, PC12 rat pheochromocytoma) within 5–7 days in a dose‐dependent manner. This effect is regulated by the concentration of serum
## Abstract Central nervous system (CNS) development requires mechanisms for the regulation of cell number. Although growth factors are essential determinants of the proliferation and apoptosis that determine final numbers, the long‐range nature of signals from diffusible growth factors makes them