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Growth Factors and Wound Healing: Platelet-Derived Growth Factor as a Model Cytokine

✍ Scribed by Deuel, Thomas F.; Kawahara, Rodney S.; Mustoe, Thomas A.; Pierce, Glenn F.

Book ID
120436302
Publisher
Annual Reviews
Year
1991
Tongue
English
Weight
715 KB
Volume
42
Category
Article
ISSN
0066-4219

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Platelet-derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes-macrophages and fibroblasts in vitro, cell types considered essential for tissue repair. Therefore, we analyzed the influence o

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Wound healing can no longer be considered a generic term: it is the summation of a complex series of processes beginning with coagulation and ending in remodelling. This review, therefore, summarizes the past year's advances in growth factor research according to the roles of the individual growth f