The autocrine hypothesis of neoplastic transformation originally stated that transformed cells escaped normal growth restraints by the production of and autostimulation by endogenous growth factors. This hypothesis followed the demonstration by DeLarco and Todaro [l] that murine sarcoma virus-transf
โฆ LIBER โฆ
Growth Factor-regulated Pathways in Epithelial Cell Proliferation
โ Scribed by Aaronson, Stuart A.; Rubin, Jeffrey S.; Finch, Paul W.; Wong, Jane; Marchese, Cinzia; Falco, Joseph; Taylor, William G.; Kraus, Matthias H.
- Book ID
- 120201013
- Publisher
- American Thoracic Society
- Year
- 1990
- Tongue
- English
- Weight
- 546 KB
- Volume
- 142
- Category
- Article
- ISSN
- 1073-449X
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JORMA KESKI-OJA Two types of transforming growth factors (TGF) have been purified and well characterized, TGFa and TGFP. TGFa is a 5.6 kD single chain molecule that shows sequence homology to epidermal growth factor (EGF), binds to the EGF receptor, and has biological effects very similar to those o