Growth factor (M-CSF) and antigenic properties of macrophages in meningioma

✍ Scribed by Bruno Giometto; Felice Bozza; Paolo Gallo; Silvana Pagni; Vincenza Argentiero; Salvatore Ferla; Salvatore Mingrino; Bruno Tavolato

• Book ID: 104651182
• Publisher: Springer US
• Year: 1992
• Tongue: English
• Weight: 718 KB
• Volume: 13
• Category: Article
• ISSN: 0167-594X
• DOI: 10.1007/bf00172943

✦ Synopsis

In meningiomas, transformed meningeal cells can share morphological aspects (in hemangiopericytic meningioma) and antigenic properties (i.e.: HLA-DR antigens expression) with elements of the monocyte/macrophage lineage. In this report, we describe a case of a highly vascular meningioma where numerous tumor cells, studied with immunohistochemical methods, present phenotypic properties of macrophages. Moreover, the cerebrospinal fluid (CF) analysis disclosed, using a biological assay, a high level of a growth factor for monocytic elements, the Macrophages Colony Stimulating Factor (M-CSF). Our findings may confirm that transitional aspects between different mesenchymal cells could be present in meningiomas.