𝔖 Bobbio Scriptorium
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Growth cone inhibition – an important mechanism in neural development?

✍ Scribed by Jamie A. Davis; Geoffrey M. W. Cook

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
680 KB
Volume
13
Category
Article
ISSN
0265-9247

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✦ Synopsis

Since the growth cone was first described a century ago by Cajal, considerable effort has been directed towards understanding the mechanisms responsible for its guidance. Traditionally, attention has focussed on the role of adhesive molecules in determining neural development. Recently, it has become apparent that inhibitory interactions may play a crucial part in axonal navigation. A common feature of inhibition seen in three model systems (peripheral nerve segmentation, retinotectal mapping and CNS/PNS segregation) is a collapse of the motile structures of the growth cone. It is increasingly clear that the identification of molecular mechanisms of inhibition, as well as those of adhesion, will be of fundamental importance to understanding neural development.

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