Growing triplet repeats
β Scribed by Lindblad, K.; Zander, C.; Schalling, M.; Hudson, T.
- Book ID
- 109916217
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 173 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1061-4036
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## Abstract Triplet repeat expansion is the molecular basis for several human diseases. Intensive studies using systems in bacteria, yeast, flies, mammalian cells, and mice have provided important insights into the molecular processes that are responsible for mediating repeat instability. The ageβd
It is well known that in some places of the human genome one finds a variable number of tandem repeats of trinucleotides; it is now commonly acknowledged that in many cases an excessive expansion of such a number is the cause of nervous system diseases. Moreover there exist cases of genetic disorder