Group Sequential Methods with Appl to Clinical Trials

Group Sequential Methods With Applicatio

📁 Group Sequential Methods With Applications to Clinical Trials

✍ Jennison C., Turnbull B. 📂 Library 📅 1999 🌐 English

This book describes group sequential stopping rules designed to reduce average study length and control Type I and Type II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test

Group-Sequential Clinical Trials with Mu

📁 Group-Sequential Clinical Trials with Multiple Co-Objectives

✍ Toshimitsu Hamasaki, Koko Asakura, Scott R. Evans, Toshimitsu Ochiai (auth.) 📂 Library 📅 2016 🏛 Springer Japan 🌐 English

This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null hypothesis (stopping for efficacy), (2) rejecting the alternative hypothesis (stopping for futility), and (3) rejecting the null or alter

Group Sequential and Confirmatory Adapti

📁 Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

✍ Gernot Wassmer, Werner Brannath (auth.) 📂 Library 📅 2016 🏛 Springer International Publishing 🌐 English

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under

Statistical Methods for Survival Trial D

📁 Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R

✍ Jianrong Wu 📂 Library 📅 2018 🏛 CRC Press 🌐 English

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using Rprovides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint.Traditional cancer trial designs with

Statistical Methods for Survival Trial D

📁 Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R

✍ Jianrong Wu 📂 Library 📅 2018 🏛 Chapman and Hall/CRC 🌐 English

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using Rprovides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint.Traditional cancer trial designs with

Statistics Applied to Clinical Trials

📁 Statistics Applied to Clinical Trials

✍ T.J. Cleophas, Ton J. Cleophas, A.H. Zwinderman, Aeilko H. Zwinderman, T.F. Cleo 📂 Library 📅 2006 🏛 Springer 🌐 English

In 1948, the first randomized controlled trial was published by the English Medical Research Council in the "British Medical Journal". Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to little sensit