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Group I nonreciprocal inhibition in primary restless legs syndrome

✍ Scribed by Cesa Scaglione; Roberto Vetrugno; Giuseppe Plazzi; Giovanni Rizzo; Federica Provini; Pasquale Montagna; Paolo Martinelli

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
112 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Electrophysiological investigations of restless legs syndrome (RLS) have found spinal circuits impinging on motoneurones. We evaluated the H reflex threshold, latency, the Hmax/Mmax ratio, and the short latency autogenic inhibition in 7 patients with RLS and 10 age‐matched controls by testing the excitability changes in soleus H reflex Ib interneuron function. A significant reduction in Ib inhibition at 4 (P = 0.043), 5 (P = 0.007), and 6 ms (P = 0.001) of H reflex conditioning interstimulus interval was found in RLS patients. Data support the hypothesis that altered group I nonreciprocal inhibition is implicated in enhancing the spinal circuitry excitability of RLS, and are consistent with the view of an abnormal supraspinal drive to spinal interneurons in RLS. © 2007 Movement Disorder Society

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