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Green synthesis of highly substituted pyridines via the one-pot multi-component reaction in 2,2,2-trifluoroethanol

โœ Scribed by Daryabari, Mehdi; Khaksar, Samad


Book ID
126490432
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
330 KB
Volume
198
Category
Article
ISSN
0167-7322

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The synthesis of 2-substituted azoles th
โœ Yijun Deng; Dennis J. Hlasta ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 87 KB

We have discovered a new reaction whereby 2-substituted azoles are formed in the reaction of an azolium ylide with reactive carbonyl compounds. These products contain a leaving group in the a-position, which on solvolysis in the presence of nucleophiles yield azoles with a variety of a-substituents.