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Green synthesis of fused pyrimido derivatives in aqueous medium

✍ Scribed by Mazaahir Kidwai; Kavita Singhal

Book ID
102340224
Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
284 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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The synthesis of nitrogen containing heterocycles from arylidene barbituric acid and various ammonia derivatives such as phenylhydrazine hydrochloride, hydroxylamine hydrochloride and aminoguanidine hydrochloride via a simple and efficient cyclocondensation in an alkaline aqueous medium is described. This improved greener synthetic methodology provides a convenient direct approach using water as a green solvent and potassium carbonate (K~2~CO~3~) as a green base for the synthesis of pyrazolopyrimidines, isoxazolopyrimidines and pyrimidopyrimidines in excellent yields.

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ChemInform Abstract: Green Synthesis of
ChemInform Abstract: Green Synthesis of Fused Pyrimido Derivatives in Aqueous Medium.
✍ Mazaahir Kidwai; Kavita Singhal πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons βš– 34 KB πŸ‘ 2 views

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