“Green synthesis” of benzothiazepine library of indeno analogues and theirin vitroantimicrobial activity

✍ Scribed by Acharya, Ashok P.; Kamble, Rahul D.; Patil, Snehalkumar D.; Hese, Shrikant V.; Yemul, Omprakash S.; Patil, Sudhakar G.; Halale, Shivshankar N.; Dawane, Bhaskar S.

• Book ID: 125406634
• Publisher: Versita
• Year: 2014
• Tongue: English
• Weight: 206 KB
• Volume: 68
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-013-0496-4

✦ Synopsis

Abstract

A novel series of indeno-benzothiazepine derivatives was synthesised via a “green” route. Synthesis of these compounds involves the treatment of dinucleophiles such as 2-aminobenzenethiols with α,β-unsaturated ketones in poly(oxyethylene) (poly(ethylene glycol), PEG-400) catalysed by acetic acid. The synthone α,β-unsaturated ketones were obtained by Claisen-Schmidt condensation of indan-1-one with substituted pyrazole-2-carbaldehydes prompted by bleaching earth (pH 12.5) as catalyst and PEG-400 as “green” reaction solvent. Screening of all the synthesised compounds for antimicrobial activity revealed that most of these compounds exhibited moderate to significant antimicrobial activity.