Green Preparation Process, Characterization and Antitumor Effects of Doxorubicin–BSA–Dextran Nanoparticles
✍ Scribed by Wei Deng; Juan Li; Ping Yao; Fen He; Chong Huang
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 372 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
In this report, we developed a simple and green process of simultaneous formation of doxorubicin–BSA–dextran nanoparticles in aqueous solution and high‐effective encapsulation of doxorubicin. In the presence of BSA–dextran conjugates, which were produced by Maillard reaction, a binding of doxorubicin with BSA can suppress the self‐aggregation of unprotonated doxorubicin. After a heat treatment, the gelation of BSA results in a formation of the nanoparticles and the doxorubicin was fixed inside the nanoparticles. The dextran shell makes the nanoparticles dispersible in solution. The nanoparticles have a spherical morphology and a hydrodynamic radius of about 90 nm. Importantly, the nanoparticles can significantly prolong the life of murine ascites hepatoma H22 tumor‐bearing mice.
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