Grecocyclines: New Angucyclines from Streptomyces sp. Acta 1362

✍ Scribed by Thomas Paululat; Andreas Kulik; Heike Hausmann; Amalia D. Karagouni; Heidi Zinecker; Johannes F. Imhoff; Hans-Peter Fiedler

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 223 KB
• Volume: 2010
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201000054

✦ Synopsis

Abstract

Two novel angucyclines were isolated from the streptomycete Acta 1362. The strain was of particular interest regarding the production of characteristic metabolites that were detected by HPLC–diode array profiling of the extracts. Grecocycline A and B were isolated and their structures were determined. Grecocycline A shows cytotoxic activity and grecocycline B inhibits protein tyrosine phosphatase 1B. Moreover, shunt product grecocyline C was isolated and its structure was determined.